Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections

A key issue in signal transduction is how signaling pathways common to many systems-so-called canonical signaling cassettes-integrate signals from molecules having a wide spectrum of activities, such as hormones and neurotrophins, to deliver distinct biological outcomes. The neuroendocrine cell line...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-05, Vol.296 (5573), p.1648-1649
Main Authors: Vaudry, D., Stork, P. J. S., Lazarovici, P., Eiden, L. E.
Format: Article
Language:English
Subjects:
Animals
Audio Equipment
Cell Differentiation
Cell Division
Cellular biology
Cellular signal transduction
Cyclic AMP - metabolism
Epidermal Growth Factor - metabolism
Epidermal Growth Factor - pharmacology
Fatty acids
Feedback (Response)
Gene expression regulation
Genes
Hormones
Individualized Instruction
Logical Thinking
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases - metabolism
Models, Biological
Molecules
Nerve Growth Factor - metabolism
Nerve Growth Factor - pharmacology
Neurites
Neurites - physiology
Neuropeptides - metabolism
Neuropeptides - pharmacology
Neuroscience
PC12 cells
PC12 Cells - physiology
Pituitary Adenylate Cyclase-Activating Polypeptide
Proteins
Rats
Receptor, trkA - metabolism
Receptors
Receptors, Cell Surface - metabolism
Response Elements
Signal transduction
Transcription, Genetic
Viewpoints and Connections Maps
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Summary:A key issue in signal transduction is how signaling pathways common to many systems-so-called canonical signaling cassettes-integrate signals from molecules having a wide spectrum of activities, such as hormones and neurotrophins, to deliver distinct biological outcomes. The neuroendocrine cell line PC12, derived from rat pheochromocytoma, provides an example of how one canonical signaling cassette-the Raf → mitogen-activated protein kinase kinase (MEK) → extracellular signal-regulated kinase (ERK) pathway-can promote distinct outcomes, which in this case include neuritogenesis, gene induction, and proliferation. Two growth hormones, epidermal growth factor (EGF) and nerve growth factor (NGF), use the same pathway to cause PC12 proliferation and differentiation, respectively. In addition, pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotransmitter that also causes differentiation, uses the same canonical cassette as NGF but in a different way. The Connections Map for PC12 Cell Differentiation brings into focus the complex array of specific cellular responses that rely on canonical signal transduction systems.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1071552