Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association si...

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Published in:	Science (American Association for the Advancement of Science) 2007-06, Vol.316 (5829), p.1336-1341
Main Authors:	Weedon, Michael N, Lindgren, Cecilia M, Timpson, Nicholas J, Freathy, Rachel M, Morris, Andrew P, Walker, Mark, Doney, Alex S.F, Clayton, David G, Craddock, Nick, Deloukas, Panos, Ouwehand, Willem H, Todd, John A, Evans, David, Leung, Hin-Tak, Attwood, Antony P, Boorman, James P, Everson, Ursula, Knight, Alexandra S, Stevens, Helen E, Walters, Graham R, Walker, Neil M, Winzer, Thilo, Ring, Susan M, Strachan, David P, Pembrey, Marcus, Fraser, Christine, Jones, Ian R, Kirov, George, Williamson, Richard, Young, Allan H, Ferrier, I. Nicol, Iles, Mark M, Maqbool, Azhar, Hall, Alistair S, Braund, Peter S, Stevens, Suzanne, Thompson, John R, Bredin, Francesca, Lees, Charles W, Forbes, Alastair, Lewis, Cathryn M, Prescott, Natalie J, Todhunter, Catherine E, Ahmad, Tariq, Cummings, Fraser R, Jewell, Derek P, Webster, John, Connell, John, Dominiczak, Anna, Gungadoo, Johannie, Lee, Kate L, Munroe, Patricia B, Onipinla, Abiodun, Caulfield, Mark, Farrall, Martin, Potter, Catherine, Silman, Alan J, Worthington, Jane, Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Farrar, Claire, Brown, Matthew A, Simmonds, Matthew J, Gough, Stephen C.L, Ban, Maria, Goris, An, Compston, Alastair, Hunt, Sarah E, Inouye, Michael, McGinnis, Ralph, Widden, Claire, Su, Zhan, Teo, Yik Ying, Ouwehand, Nilesh J, Samani, Michael R, Ardern-Jones, A, Brice, G, Castle, B, Donaldson, A, Eeles, R, Goodman, S, Gray, J, Greenhalgh, L, Hodgson, S.V, Izatt, L, Jeffers, L, Locke, I, Longmuir, M, Mackay, J, Magee, A, Miedzybrodzka, Z, Paterson, J, Porteous, M, Rowe, S, Shanley, S, Saggar, A, Side, L, Steel, M, Thomas, M
Format:	Article
Language:	eng
Subjects:	Adult Aged Biological and medical sciences Biomedical research Case-Control Studies Cellular biology Chromosome Mapping Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Forestry research Genes, p16 Genetic loci Genetic Predisposition to Disease Genetic research Genome, Human Genomics Homeodomain Proteins - genetics Hospital buildings Hospital units Human genetics Humans Insulin-Like Growth Factor Binding Proteins - genetics Introns Male Medical genetics Medical research Medical sciences Meta-Analysis as Topic Middle Aged Molecular biology Oligonucleotide Array Sequence Analysis Pancreas Polymorphism, Single Nucleotide Population genetics Research universities Transcription Factors - genetics Type 2 diabetes mellitus United Kingdom
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