Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses

In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influ...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2001-09, Vol.293 (5536), p.1840-1842
Main Authors:	Hatta, Masato, Gao, Peng, Halfmann, Peter, Kawaoka, Yoshihiro
Format:	Article
Language:	eng
Subjects:	Amino Acid Sequence Amino acids Analysis Animals Biological and medical sciences Birds - virology Communicable diseases DNA, Recombinant - genetics Fundamental and applied biological sciences. Psychology Genetic mutation Genetics H5N1 subtype influenza A virus Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism Hong Kong - epidemiology Humans Infections Influenza Influenza A virus Influenza A virus - genetics Influenza A virus - pathogenicity Influenza A virus - physiology Influenza A Virus, H5N1 Subtype Influenza viruses Influenza, Human - epidemiology Influenza, Human - mortality Influenza, Human - transmission Influenza, Human - virology Kidney cells Lung - virology Mice Microbiology Mutation, Missense - genetics Pandemics Proteins Reassortant Viruses - genetics Reassortant Viruses - pathogenicity Reassortant Viruses - physiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA Replicase Rodents Transcriptional regulatory elements Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virology Virulence Viruses
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