Lack of Replicative Senescence in Normal Rodent Glia

Replicative senescence is thought to be an intrinsic mechanism for limiting the proliferative life-span of normal somatic cells. We show here that rat Schwann cells can be expanded indefinitely in culture while maintaining checkpoints normally lost during the immortalization process. These findings...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2001-02, Vol.291 (5505), p.872-875
Main Authors: Mathon, Nicole F., Malcolm, Denise S., Harrisingh, Marie C., Cheng, Lili, Lloyd, Alison C.
Format: Article
Language:English
Subjects:
Aging
Anatomy
Animals
beta-Galactosidase - metabolism
Biological and medical sciences
Blood
Carrier Proteins - metabolism
Cell aging
Cell Culture Techniques
Cell cycle
Cell cycle, cell proliferation
Cell Division
Cell growth
Cell Line
Cell lines
Cell physiology
Cell Size
Cells
Cells, Cultured
Cellular biology
Cellular Senescence
Clone Cells
Culture Conflict
Culture Media
Cultured cells
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases - metabolism
Cyclins - metabolism
Fibroblasts
Fibroblasts - cytology
Fibroblasts - physiology
Fundamental and applied biological sciences. Psychology
Genetic aspects
Genetic research
Giant cells
Giant Cells - cytology
Glia
Logical Thinking
Molecular and cellular biology
Mutation
Neuroglia
Phenotype
Proteins - metabolism
ras Proteins - metabolism
Rats
Rattus
Rodents
Schwann cells
Schwann Cells - cytology
Schwann Cells - physiology
Somatic cells
Telomerase - metabolism
Telomere - physiology
Tumor Suppressor Protein p14ARF
Tumor Suppressor Protein p53 - metabolism
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Description
Summary:Replicative senescence is thought to be an intrinsic mechanism for limiting the proliferative life-span of normal somatic cells. We show here that rat Schwann cells can be expanded indefinitely in culture while maintaining checkpoints normally lost during the immortalization process. These findings demonstrate that senescence is not an inevitable consequence of extended proliferation in culture.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1056782