G Protein-Coupled Receptor-Dependent Development of Human Frontal Cortex

The mammalian cerebral cortex is characterized by complex patterns of anatomical and functional areas that differ markedly between species, but the molecular basis for this functional subdivision is largely unknown. Here, we show that mutations in GPR56, which encodes an orphan G protein-coupled rec...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2004-03, Vol.303 (5666), p.2033-2036
Main Authors:	Piao, Xianhua, Hill, R. Sean, Bodell, Adria, Chang, Bernard S., Basel-Vanagaite, Lina, Straussberg, Rachel, Dobyns, William B., Qasrawi, Bassam, Winter, Robin M., Innes, A. Micheil, Voit, Thomas, Ross, M. Elizabeth, Michaud, Jacques L., Déscarie, Jean-Claude, Barkovich, A. James, Walsh, Christopher A.
Format:	Article
Language:	eng
Subjects:	Amino Acid Substitution Amino acids Anatomy & physiology Animals Antisense Elements (Genetics) bilateral frontoparietal polymicrogyria Biological and medical sciences Biological Evolution Body Patterning Brain Cells Cerebral cortex Cerebral Cortex - abnormalities Cerebral Cortex - embryology Cerebral Ventricles - cytology Cerebral Ventricles - embryology Cousins Development. Senescence. Regeneration. Transplantation Exons Female Frameshift Mutation French Canadians Frontal Lobe - abnormalities Frontal Lobe - embryology Fundamental and applied biological sciences. Psychology Gene Order Genes Genetic aspects Genetic Disorders Genetic mutation Genetics GPR56 protein Humans Language Impairments Ligands Male Mice Mutation Mutation, Missense Neurons Neurons - physiology Parietal Lobe - abnormalities Parietal Lobe - embryology Patients Progenitor cells Proteins Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Sequence Deletion Sequence Homology, Amino Acid Signal Transduction Splicing Stem Cells - physiology Vertebrates: nervous system and sense organs
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