Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21

Global patterns of human DNA sequence variation (haplotypes) defined by common single nucleotide polymorphisms (SNPs) have important implications for identifying disease associations and human traits. We have used high-density oligonucleotide arrays, in combination with somatic cell genetics, to ide...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2001-11, Vol.294 (5547), p.1719-1723
Main Authors:	Patil, Nila, Berno, Anthony J., Hinds, David A., Barrett, Wade A., Doshi, Jigna M., Hacker, Coleen R., Kautzer, Curtis R., Lee, Danny H., Marjoribanks, Claire, McDonough, David P., Bich T. N. Nguyen, Norris, Michael C., Sheehan, John B., Shen, Naiping, Stern, David, Stokowski, Renee P., Thomas, Daryl J., Trulson, Mark O., Vyas, Kanan R., Frazer, Kelly A., Stephen P. A. Fodor, Cox, David R.
Format:	Article
Language:	eng
Subjects:	Algorithms Alleles Animals Biological and medical sciences chromosome 21 Chromosome mapping Chromosomes Chromosomes, Human, Pair 21 - genetics Continental Population Groups - genetics Deoxyribonucleic acid Disease DNA Ethnic Groups - genetics Fundamental and applied biological sciences. Psychology Gene Frequency - genetics Genes Genetic aspects Genetic diversity Genetic Variation - genetics Genome, Human Genomics Haplotypes Haplotypes - genetics Human chromosome 21 Human genome Humans Hybrid Cells - metabolism Molecular and cellular biology Mutation - genetics Nucleotide sequences Nucleotides Oligonucleotide Array Sequence Analysis - methods Oligonucleotides Polymorphism, Single Nucleotide - genetics Random Allocation Sensitivity and Specificity
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