Delay of Tumor Growth in Hamsters Treated With Lynestrenol and Effect of Staphylococcus aureus Cowan A

The action of lynestrenol, a synthetic progesteronelike substance, was studied in Syrian golden hamsters inoculated with cells transformed by herpes simplex virus type I. Daily ip injections of 1 mg lynestrenol/kg delayed tumor growth. Lynestrenol alone only slightly increased the survival of the an...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1978-07, Vol.61 (1), p.173-176
Main Authors: Wybran, Joseph, Thiry, Lise
Format: Article
Language:English
Subjects:
Animals
Antigens, Neoplasm - administration & dosage
Cell Transformation, Neoplastic
Cricetinae
Female
Immunity - drug effects
Immunotherapy
Lynestrenol - pharmacology
Male
Mesocricetus
Neoplasm Transplantation
Neoplasms, Experimental - etiology
Neoplasms, Experimental - immunology
Neoplasms, Experimental - therapy
Simplexvirus
Staphylococcus aureus - immunology
Transplantation, Homologous
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The action of lynestrenol, a synthetic progesteronelike substance, was studied in Syrian golden hamsters inoculated with cells transformed by herpes simplex virus type I. Daily ip injections of 1 mg lynestrenol/kg delayed tumor growth. Lynestrenol alone only slightly increased the survival of the animals. This effect was more marked when the animals were also given injections of Staphylococcus aureus Cowan A. Survivors showed an increased resistance to challenge with infected cells. Hamsters previously given injections of killed transformed cells and then challenged with living cells showed a facilitation of tumor growth. This facilitation was inhibited by lynestrenol alone or combined with S. aureus Cowan A.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/61.1.173