Estrogen receptor assay on breast cancer microsamples: Implications of percent carcinoma estimation

Forty‐milligram strips of malignant breast tissue were divided longitudinally into 20‐mg microsamples. Soluble protein concentration was determined for one‐half, and histologic evaluation for viable carcinoma content was made on its sister half. The correlation coefficient for 88 such comparisons wa...

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Bibliographic Details
Published in:Cancer 1982-06, Vol.49 (11), p.2383-2388
Main Authors: van Netten, Johannes P., Algard, F. Thomas, Coy, Peter, Carlyle, Sheila J., Brigden, Malcolm L., Thornton, Kenneth R., To, Mary P.
Format: Article
Language:English
Subjects:
Animals
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cattle
Endometrium - metabolism
Female
Humans
Microchemistry
Receptors, Estrogen - metabolism
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Summary:Forty‐milligram strips of malignant breast tissue were divided longitudinally into 20‐mg microsamples. Soluble protein concentration was determined for one‐half, and histologic evaluation for viable carcinoma content was made on its sister half. The correlation coefficient for 88 such comparisons was 0.330. This suggests that estrogen receptor (ER) assays that do not take into account the actual amount of carcinoma present in the sample may not permit reliable stratification of ER data. Using this technique, ER values obtained for 129 breast tumor microsamples were adjusted to reflect carcinoma content. A comparison of ER values before and after such adjustment revealed that the relative status of 73% was not significantly changed. The ER status of 27%, however, was changed sufficiently to be of potential clinical significance.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19820601)49:11<2383::AID-CNCR2820491127>3.0.CO;2-G