EFFECT OF PHYSOSTIGMINE ON MORPHINE-INDUCED POSTOPERATIVE PAIN AND SOMNOLENCE

The effects of physostigmine 1 mg I V were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10mg/60kg 1 v in 10 patients recovering from surgery. Within 5–10min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1982-04, Vol.54 (4), p.429-434
Main Authors: WEINSTOCK, M., DAVIDSON, J.T., ROSIN, A.J., SCHNIEDEN, H.
Format: Article
Language:English
Subjects:
Adult
Aged
Humans
Hypnotics and Sedatives - antagonists & inhibitors
Male
Middle Aged
Morphine - antagonists & inhibitors
Morphine - therapeutic use
Pain, Postoperative - drug therapy
Physostigmine - pharmacology
Physostigmine - therapeutic use
Respiration - drug effects
Sleep Stages - drug effects
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Summary:The effects of physostigmine 1 mg I V were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10mg/60kg 1 v in 10 patients recovering from surgery. Within 5–10min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40–60 min
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/54.4.429