all-trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery after balloon withdrawal injury

The multifactorial and unpredictable nature of human restenosis will probably necessitate interventional strategies that target multiple processes involved in acute vascular narrowing. Retinoids (eg, all-trans-retinoic acid, atRA) represent a growing class of pleiotropic biological response modifier...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1998-09, Vol.98 (12), p.1219-1227
Main Authors: MIANO, J. M, KELLY, L. A, ARTACHO, C. A, NUCKOLLS, T. A, PIANTEDOSI, R, BLANER, W. S
Format: Article
Language:English
Subjects:
Actins - analysis
Actins - immunology
Animals
Biological and medical sciences
Carotid Arteries - drug effects
Carotid Arteries - pathology
Diseases of the cardiovascular system
DNA - biosynthesis
Male
Medical sciences
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - pathology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Rats
Rats, Sprague-Dawley
Tretinoin - pharmacokinetics
Tretinoin - pharmacology
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Summary:The multifactorial and unpredictable nature of human restenosis will probably necessitate interventional strategies that target multiple processes involved in acute vascular narrowing. Retinoids (eg, all-trans-retinoic acid, atRA) represent a growing class of pleiotropic biological response modifiers with demonstrable efficacy in managing several pathological conditions. In this report, we have initiated studies to examine the hypothesis that atRA limits neointimal formation after experimental vascular injury. Rats were predosed with atRA (30 mg . kg-1 . d-1 PO) or corn oil 4 days before balloon withdrawal injury (BWI) of the left common carotid artery and continued on this drug regimen for an additional 14 days. High-performance liquid chromatographic analysis documented therapeutic levels of atRA in serum and vascular tissue. atRA depressed peak DNA synthesis in the tunica media of BWI vessels (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.98.12.1219