Effect of direct thrombin inhibition with Bivalirudin (Hirulog) on restenosis after coronary angioplasty

The direct antithrombin, bivalirudin, did not reduce angiographic restenosis measured either as the dichotomous restenosis rate of 62% for bivalirudin and 58% for heparin (p = 0.70), or as the late loss in lumen diameter of 0.44 +/- 0.47 mm for bivalirudin and 0.39 +/- 0.53 mm for heparin (p = 0.62)...

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Bibliographic Details
Published in:The American journal of cardiology 1998-08, Vol.82 (4), p.511-515
Main Authors: Burchenal, J.E.B., Marks, David S., Mann, J.Tift, Schweiger, Marc J., Rothman, Martin T., Ganz, Peter, Adelman, Burt, Bittl, John A.
Format: Article
Language:English
Subjects:
Adult
Aged
Angioplasty, Balloon, Coronary
Antithrombins - therapeutic use
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cardiology
Coronary Disease - diagnostic imaging
Coronary Disease - prevention & control
Coronary Disease - therapy
Drug therapy
Female
Heparin - therapeutic use
Hirudin Therapy
Hirudins - analogs & derivatives
Humans
Linear Models
Male
Medical sciences
Middle Aged
Peptide Fragments - therapeutic use
Pharmacology. Drug treatments
Radiography
Recombinant Proteins - therapeutic use
Recurrence
Risk Factors
Surgery
Treatment Outcome
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Summary:The direct antithrombin, bivalirudin, did not reduce angiographic restenosis measured either as the dichotomous restenosis rate of 62% for bivalirudin and 58% for heparin (p = 0.70), or as the late loss in lumen diameter of 0.44 +/- 0.47 mm for bivalirudin and 0.39 +/- 0.53 mm for heparin (p = 0.62). Direct thrombin inhibition with bivalirudin neither reduces angiographic restenosis nor alters the impact of several established risk factors for restenosis.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00371-3