BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation

Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily, have critical functions in many biological contexts. Recent findings in Drosophila and vertebrates suggest that BMP signaling can be modulated extracellularly and intracellularly by the availability of BMP inhibitors and Smads, re...

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Bibliographic Details
Published in:Current opinion in genetics & development 1998-08, Vol.8 (4), p.443-449
Main Authors: Cho, Ken WY, Blitz, Ira L
Format: Article
Language:English
Subjects:
Animals
Bone Morphogenetic Proteins - metabolism
Metalloendopeptidases - metabolism
Signal Transduction
Transforming Growth Factor beta - metabolism
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Summary:Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily, have critical functions in many biological contexts. Recent findings in Drosophila and vertebrates suggest that BMP signaling can be modulated extracellularly and intracellularly by the availability of BMP inhibitors and Smads, respectively.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(98)80116-0