Chemoprophylaxis of Theileria annulata and Theileria parva infections of calves with buparvaquone

A clinical trial testing the prophylactic effect of a 5 mg kg −1 dose of buparvaquone on either Theileria annulata or Theileria parva experimental infections of calves demonstrated its efficacy for periods of at least seven days. The drug given 1 h or seven days before 50% lethal T. annulata sporozo...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary parasitology 1998-07, Vol.78 (1), p.1-12
Main Authors: Wilkie, G.M., Brown, C.G.D., Kirvar, E., Thomas, M., Williamson, S.M., Bell-Sakyi, L.J., Sparagano, O.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Protozoan - blood
Antiprotozoal Agents - therapeutic use
Buparvaquone
CALVES
Cattle
Cattle-Protozoa
CHEMOPROPHYLAXIS
CHIMIOPREVENTION
CONTROL DE PLAGAS
CONTROL METHODS
Control methods-Protozoa
Fluorescent Antibody Technique, Indirect
LUTTE ANTIRAVAGEUR
METHODE DE LUTTE
METODOS DE CONTROL
Naphthoquinones - therapeutic use
OXITETRACICLINA
OXYTETRACYCLINE
Parasitemia - immunology
Parasitemia - prevention & control
Parasitemia - veterinary
PEST CONTROL
PROFILAXIS QUIMICA
TERNERO
THEILERIA ANNULATA
Theileria annulata - immunology
THEILERIA PARVA
Theileria parva - immunology
Theileria spp
Theileriasis - immunology
Theileriasis - prevention & control
VEAU
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A clinical trial testing the prophylactic effect of a 5 mg kg −1 dose of buparvaquone on either Theileria annulata or Theileria parva experimental infections of calves demonstrated its efficacy for periods of at least seven days. The drug given 1 h or seven days before 50% lethal T. annulata sporozoite infection protected all eight calves, but prophylaxis was insufficient after 14 days to protect two out of four calves from severe reaction. When immunity was challenged by a lethal second parasite dose a month after the first, all these calves were immune. In the T. parva trial, calves given drug 1 h or seven days before a 25% lethal infection underwent minimal reactions, but some were over-protected and were susceptible to a similar challenge sporozoite dose. Although drug levels remaining 14 days after prophylaxis protected these calves from the mild challenge, some parameters measured were within the range of the `no drug' control group. These results indicate the effectiveness of a single 5 mg kg −1 dose of buparvaquone for more than seven days but also the potential risk of its use in the infection and treatment method of immunisation. It is suggested that there may be circumstances where simple field prophylactic treatment with buparvaquone may be beneficial.
ISSN:0304-4017
1873-2550
DOI:10.1016/S0304-4017(98)00126-5