Distribution of CCR5-delta 32 gene deletion across the Russian part of Eurasia

32-bp inactivating deletion in the beta-chemokine receptor 5 (CCR5) gene, common in Nothern European populations, is associated with reduced HIV-1 transmission risk and delayed disease progression. We have studied the deletion distribution in many populations in Eurasia by polymerase chain reaction...

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Bibliographic Details
Published in:Human genetics 1998-06, Vol.102 (6), p.695-698
Main Authors: Yudin, N S, Vinogradov, S V, Potapova, T A, Naykova, T M, Sitnikova, V V, Kulikov, I V, Khasnulin, V I, Konchuk, C, Vloschinskii, P E, Ivanov, S V, Kobzev, V F, Romaschenko, A G, Voevoda, M I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
AIDS/HIV
Child
Ethnic Groups - genetics
Female
Gene Deletion
Gene Frequency
Humans
Male
Middle Aged
Polymerase Chain Reaction
Receptors, CCR5 - genetics
Russia
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Summary:32-bp inactivating deletion in the beta-chemokine receptor 5 (CCR5) gene, common in Nothern European populations, is associated with reduced HIV-1 transmission risk and delayed disease progression. We have studied the deletion distribution in many populations in Eurasia by polymerase chain reaction analysis of 531 DNA samples representing West and East Siberian, Central Asian, and Far Eastern parts of Russia. An unusually high frequency (11.1%) of the deleted variant in natives of West Siberia, of Finno-Ugrian descent, was observed. Furthermore, the deletion was infrequent in indigenous populations of Central Asia, East Siberia, the Russian Far East, and Canada. We conclude that the delta(ccr5) distribution is limited primarily to Europeans and related western Siberian Finno-Ugrian populations, with a sharp negative gradient toward the east along the territory of Russian Asia.
ISSN:0340-6717
1432-1203
DOI:10.1007/s004390050764