Biological efficacy and signal transduction through STAT proteins of recombinant duck interferon in duck hepatitis B virus infection

The aim of this study was to characterize the interferon induced intracellular signals in duck hepatocytes and to investigate the effects of duck interferon on virus replication in duck hepatitis B virus (DHBV) infected ducks. Interestingly, duck interferon was found to activate intracellular signal...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of general virology 1998-08, Vol.79 (8), p.2007-2012
Main Authors:	Heuss, L.T, Heim, M.H, Schultz, U, Wissmann, D, Offensperger, W.B, Staeheli, P, Blum, H.E
Format:	Article
Language:	eng
Subjects:	animal diseases animal health Animals Cells, Cultured DNA-Binding Proteins - metabolism duck hepatitis virus Ducks Hepadnaviridae Infections - metabolism Hepadnaviridae Infections - virology Hepatitis B Virus, Duck Humans Interferon-Stimulated Gene Factor 3 Interferon-Stimulated Gene Factor 3, gamma Subunit Interferons - metabolism Interferons - pharmacology Liver - cytology Liver - metabolism Liver - virology Milk Proteins Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Signal Transduction STAT1 Transcription Factor STAT2 Transcription Factor STAT3 Transcription Factor STAT4 Transcription Factor STAT5 Transcription Factor STAT6 Transcription Factor Trans-Activators - metabolism Transcription Factors - metabolism viral diseases of animals and humans
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The aim of this study was to characterize the interferon induced intracellular signals in duck hepatocytes and to investigate the effects of duck interferon on virus replication in duck hepatitis B virus (DHBV) infected ducks. Interestingly, duck interferon was found to activate intracellular signal transduction pathways similar to those of its mammalian counterparts. An interferon stimulated gel shift activity like that of gene factor 3 is induced, as well as serum inducible element binding factors homologous to serum inducible factor A (SIF-A), SIF-B and SIF-C. Duck interferon induced signal transducer and activator of transcription activation is not inhibited by DHBV infection of hepatocytes. DHBV infected ducks treated for 10 days with recombinant duck interferon show a decrease in viral DNA in hepatocytes, and in many cases disappearance of viraemia. These findings confirm the usefulness of the DHBV infection model for the study of human hepatitis B virus infection.
ISSN:	0022-1317 1465-2099