Induction of Hyphae in Cultures of Pityrosporum by Cholesterol and Cholesterol Esters

The effect of cholesterol and cholesterol esters on Pityrosporum cultures has been studied. A mixture from 0.25% to 2.0% of cholesterol:cholesteryl stearate:glyceryl mono-stearate (2.0:1.5:2.0) added to Bacto Yeast Morphology Agar plus oleic acid was able to induce hyphae in cultures of both Pityros...

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Bibliographic Details
Published in:Journal of investigative dermatology 1977-12, Vol.69 (6), p.531-534
Main Authors: Porro, Marcella Nazzaro, Passi, Siro, Caprilli, Federico, Mercantini, Rinaldo
Format: Article
Language:English
Subjects:
Cell Membrane - drug effects
Cholesterol - pharmacology
Cholesterol Esters - pharmacology
Humans
Malassezia - drug effects
Malassezia - ultrastructure
Tinea Versicolor - etiology
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Summary:The effect of cholesterol and cholesterol esters on Pityrosporum cultures has been studied. A mixture from 0.25% to 2.0% of cholesterol:cholesteryl stearate:glyceryl mono-stearate (2.0:1.5:2.0) added to Bacto Yeast Morphology Agar plus oleic acid was able to induce hyphae in cultures of both Pityrosporum orbiculare and P. ovale. This result is discussed with respect to the cholesterol effect on cell membranes and to the occurrence of cholesterol and cholesterol esters in the scaling patches of Pityriasis versicolor.
ISSN:0022-202X
1523-1747
DOI:10.1111/1523-1747.ep12687967