The feasibility of intraoperative diagnosis of sentinel lymph node metastases in breast cancer

Background and Objectives The aim of the study was to analyse in detail the feasibility of intraoperative assessment of sentinel lymph nodes in breast cancer. Methods Altogether 139 consecutive breast cancer patients with metastases in axillary sentinel nodes were included in a prospective study. A...

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Bibliographic Details
Published in:Journal of surgical oncology 2003-10, Vol.84 (2), p.68-73
Main Authors: Leidenius, Marjut Hannele Kristiina, Krogerus, Leena Anneli, Toivonen, Terttu Sinikka, von Smitten, Karl Johan Albert
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
axillary metastases
Biological and medical sciences
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Carcinoma, Ductal, Breast - diagnosis
Carcinoma, Ductal, Breast - secondary
Carcinoma, Ductal, Breast - surgery
Carcinoma, Lobular - diagnosis
Carcinoma, Lobular - secondary
Carcinoma, Lobular - surgery
Feasibility Studies
frozen section
Gynecology. Andrology. Obstetrics
Humans
immunohistochemistry
imprint cytology
Intraoperative Period
Lymphatic Metastasis
Mammary gland diseases
Medical sciences
micro-metastases
Middle Aged
Neoplasm Staging
Prospective Studies
Sensitivity and Specificity
Sentinel Lymph Node Biopsy
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Tumors
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Summary:Background and Objectives The aim of the study was to analyse in detail the feasibility of intraoperative assessment of sentinel lymph nodes in breast cancer. Methods Altogether 139 consecutive breast cancer patients with metastases in axillary sentinel nodes were included in a prospective study. A combination of imprint cytology and frozen section was used as the method of intraoperative diagnosis of sentinel node metastases. The definite postoperative evaluation of the sentinel nodes was taken as the gold standard. Results The overall sensitivity of intraoperative diagnosis was 83%, reaching 81% if the intraoperative assessment had been limited to the two first retrieved sentinel nodes. False negative (FN) findings were more common in connection with invasive lobular carcinoma (28%) than with invasive ductal carcinoma (8%) (P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.10296