Circulating alpha-2-macroglobulin levels and depression scores in patients who underwent abdominal cancer surgery

Although depression is a predominant health care problem, it is difficult to diagnose in patients who underwent abdominal cancer surgery. Relevance of elevated levels of serum of alpha-2-macroglobulin (A2M) to psychological depression has been recently suggested. Serum A2M levels were measured and d...

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Bibliographic Details
Published in:The Journal of surgical research 2003-09, Vol.114 (1), p.90-94
Main Authors: Fujita, Tetsuji, Nagayama, Akira, Anazawa, Sadao
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
alpha-2-macroglobulin
alpha-Macroglobulins - analysis
alpha-Macroglobulins - metabolism
Biological and medical sciences
colectomy
Colectomy - adverse effects
Colorectal Neoplasms - surgery
cytokine-binding protein
Depression - blood
Depression - etiology
Depression - metabolism
Female
gastrectomy
Gastrectomy - adverse effects
Gastroenterology. Liver. Pancreas. Abdomen
Hospital Anxiety and Depression Scale
Humans
Male
Medical sciences
Middle Aged
Prospective Studies
psychological depression
Severity of Illness Index
Stomach Neoplasms - surgery
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Although depression is a predominant health care problem, it is difficult to diagnose in patients who underwent abdominal cancer surgery. Relevance of elevated levels of serum of alpha-2-macroglobulin (A2M) to psychological depression has been recently suggested. Serum A2M levels were measured and depression scores were determined by the Hospital Anxiety and Depression Scale before and 1 year after abdominal cancer surgery in 45 patients. Serum levels of A2M and depression scores were significantly ( P = 0.0006, P = 0.0045, respectively) increased after total gastrectomy compared with preoperative values, whereas there was no interval change in both measurements of patients having colorectal resection. Of the patients who had undergone distal or total gastrectomy for gastric cancer, serum A2M concentrations in a depressed group were significantly higher ( P = 0.028) than those in non-depressed group. Patients with total gastrectomy are predisposed to depression, and circulating A2M elevation may be implicated in the development of postoperative depression in these patients.
ISSN:0022-4804
1095-8673
DOI:10.1016/S0022-4804(03)00194-X