Effects of aqueous extracts of Satureja hortensis L. on rhinosinusitis treatment in rabbit

Satureja hortensis L. (Lamiaceae) is an annual herb that used as traditional folk medicine in Eastern Anatolia region of Turkey for treatment of different infectious diseases and disorders. This study was designated to investigate anti-inflammatory effect of aqueous extract (250 mg/kg) of Satureja h...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2003-10, Vol.88 (2), p.225-228
Main Authors: Uslu, Celil, Karasen, R.Murat, Sahin, Fikrettin, Taysi, Seyithan, Akcay, Fatih
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Disease Models, Animal
edema
Female
infectious diseases
inflammation
Male
metabolites
Nasal Mucosa - drug effects
Nasal Mucosa - metabolism
Nasal Mucosa - pathology
nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Synthase - metabolism
NO [rad]
NOS
Plant Components, Aerial - chemistry
Plant Extracts - pharmacology
Rabbit model of rhinosinusitis
Rabbits
Rhinitis - drug therapy
Rhinitis - metabolism
Rhinitis - pathology
Satureja - chemistry
Satureja hortensis
Sinusitis - drug therapy
Sinusitis - metabolism
Sinusitis - pathology
therapeutics
traditional medicine
Water - chemistry
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Summary:Satureja hortensis L. (Lamiaceae) is an annual herb that used as traditional folk medicine in Eastern Anatolia region of Turkey for treatment of different infectious diseases and disorders. This study was designated to investigate anti-inflammatory effect of aqueous extract (250 mg/kg) of Satureja hortensis. Therapeutic potential of Satureja hortensis as an anti-inflammatory agent was examined by measurement of NO metabolites and histological changes in a rabbit model of rhinosinusitis. The results showed that both activity of NOS enzyme and concentration of NO metabolites were significantly reduced by topical administration of Satureja hortensis extract. Histological examination demonstrated no edema and/or reduced inflammation in therapy group as compared to the control. Thus, the data suggest Satureja hortensis extract may have the potential to be used as anti-inflammation agent, and can be used in the treatment of rhinosinusitis diseases.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(03)00236-8