Hypereosinophilia associated with cardiac rhabdomyosarcoma

Hypereosinophilia, defined as an absolute eosinophil count exceeding 1,500/mm3, is caused by a limited number of disorders. Its association with malignancy is a rare occurrence that typically denotes extensive metastasis and a poor prognosis. Several theories have been proposed to explain the hypere...

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Bibliographic Details
Published in:American journal of hematology 2003-09, Vol.74 (1), p.64-67
Main Authors: Lo Re, Vincent, Fox, Kevin R., Ferrari, Victor A., Scott, Craig H., Kossev, Plamen M., Kostman, Jay R.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology. Vascular system
Echocardiography
eosinophilia
Female
Heart
Heart Neoplasms - complications
Heart Neoplasms - diagnostic imaging
Heart Neoplasms - pathology
Humans
hypereosinophilia
Hypereosinophilic Syndrome - etiology
Infarction - diagnostic imaging
Infarction - etiology
Medical sciences
Renal Circulation
rhabdomyosarcoma
Rhabdomyosarcoma - complications
Rhabdomyosarcoma - diagnostic imaging
Rhabdomyosarcoma - pathology
Spleen - blood supply
Tomography, X-Ray Computed
Tumors of the heart
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Summary:Hypereosinophilia, defined as an absolute eosinophil count exceeding 1,500/mm3, is caused by a limited number of disorders. Its association with malignancy is a rare occurrence that typically denotes extensive metastasis and a poor prognosis. Several theories have been proposed to explain the hypereosinophilia associated with malignancy, focusing on the production of eosinophilopoietic cytokines by tumors. We describe a patient with hypereosinophilia associated with a cardiac rhabdomyosarcoma, review the etiologies of hypereosinophilia, and discuss the possible mechanisms. Am. J. Hematol. 74:64–67, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.10373