A-Elute alleles of the ABO blood group system in Japanese

The ABO blood group system is important in forensic genetics, as well as transfusion medicine. Since the elucidation of the molecular basis of ABO gene regulation, nucleotides of variant alleles or suballeles have been analyzed by polymerase chain reaction (PCR)-based methods and sequencing. Ael (A-...

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Bibliographic Details
Published in:Legal medicine (Tokyo, Japan) Japan), 2003-03, Vol.5, p.S207-S209
Main Authors: Okiura, Tatsuyuki, Fukumori, Yasuo, Nishimura, Koji, Orimoto, Chitoshi, Fujii, Kenji, Nishimukai, Hiroaki
Format: Article
Language:English
Subjects:
A-Elute
ABO blood group system
ABO Blood-Group System - genetics
Alleles
DNA
Ethnic Groups - genetics
Humans
Japan
Phenotype
Polymerase chain reaction
Polymerase Chain Reaction - methods
Polymorphism, Restriction Fragment Length
Restriction fragment length polymorphism
Sequencing
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Summary:The ABO blood group system is important in forensic genetics, as well as transfusion medicine. Since the elucidation of the molecular basis of ABO gene regulation, nucleotides of variant alleles or suballeles have been analyzed by polymerase chain reaction (PCR)-based methods and sequencing. Ael (A-elute) is one of the subgroups of A in the ABO system. By analyzing the suballeles responsible for Ael phenotype by PCR-RFLP and PCR direct sequencing, we found seven types of Ael allele. The allele frequency of ABO*Ael in a Japanese population was calculated to be 0.0049.
ISSN:1344-6223
1873-4162
DOI:10.1016/S1344-6223(02)00113-X