Potentially malignant oral lesions in Northern Ireland: size (extent) matters

OBJECTIVES: We examined clinical parameters of patients from Northern Ireland with potentially malignant lesions (PML) to determine association with development of intraoral squamous cell carcinoma (SCC). DESIGN: retrospective, cross‐sectional, population‐based, clinically validated, laboratory‐veri...

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Bibliographic Details
Published in:Oral diseases 2003-05, Vol.9 (3), p.129-137
Main Authors: Napier, SS, Cowan, CG, Gregg, TA, Stevenson, M, Lamey, P-J, Toner, PG
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - pathology
Cell Transformation, Neoplastic - pathology
clinical findings
Cross-Sectional Studies
Dentistry
Female
Follow-Up Studies
Humans
Leukoplakia, Oral - pathology
Lichen Planus, Oral - pathology
Lupus Erythematosus, Systemic - pathology
Male
Medical sciences
Middle Aged
Mouth Neoplasms - pathology
Northern Ireland
oral mucosa
Otorhinolaryngology. Stomatology
Population Surveillance
potentially malignant lesions
Precancerous Conditions - pathology
prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Smoking - adverse effects
squamous cell carcinoma
Survival Analysis
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:OBJECTIVES: We examined clinical parameters of patients from Northern Ireland with potentially malignant lesions (PML) to determine association with development of intraoral squamous cell carcinoma (SCC). DESIGN: retrospective, cross‐sectional, population‐based, clinically validated, laboratory‐verified. SUBJECTS AND METHODS: All patients who had more than one incisional oral mucosal biopsy diagnosed from 1975–1991 were ed from a database of all PML and SCC and their clinical records and biopsies reviewed. Patients were excluded if there was prior/synchronous SCC or radiotherapy, frictional keratosis or lichen planus, missing clinical records/biopsy material or follow‐up of
ISSN:1354-523X
1601-0825
DOI:10.1034/j.1601-0825.2003.02888.x