Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4(+)CD25(+) regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 main...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2003-10, Vol.171 (7), p.3348-3352
Main Authors: Tang, Qizhi, Henriksen, Kammi J, Boden, Elisa K, Tooley, Aaron J, Ye, Jianqin, Subudhi, Sumit K, Zheng, Xin X, Strom, Terry B, Bluestone, Jeffrey A
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - pharmacology
Antigens, CD - physiology
B7-1 Antigen - pharmacology
B7-1 Antigen - physiology
B7-2 Antigen
CD28 Antigens - metabolism
CD28 Antigens - physiology
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Cell Differentiation - immunology
Cell Division - immunology
Cell Survival - immunology
Homeostasis - immunology
Interleukin-2 - physiology
Lymph Nodes - cytology
Lymph Nodes - immunology
Lymph Nodes - metabolism
Membrane Glycoproteins - pharmacology
Membrane Glycoproteins - physiology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Knockout
Mice, Transgenic
Receptors, Interleukin-2 - biosynthesis
Spleen - cytology
Spleen - immunology
Spleen - metabolism
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Thymus Gland - cytology
Thymus Gland - immunology
Thymus Gland - metabolism
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Description
Summary:CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4(+)CD25(+) regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.171.7.3348