Combination of serum markers related to several mechanisms in Alzheimer’s disease

Alzheimer’s disease (AD) probably involves several pathobiochemical mechanisms and this may be reflected by changes in different serum components. The present study investigated whether the combined analysis of serum molecules related to different mechanisms improves the discrimination of AD patient...

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Bibliographic Details
Published in:Neurobiology of aging 2003-11, Vol.24 (7), p.893-902
Main Authors: Teunissen, C.E., Lütjohann, D., von Bergmann, K., Verhey, F., Vreeling, F., Wauters, A., Bosmans, E., Bosma, H., van Boxtel, M.P.J., Maes, M., Delanghe, J., Blom, H.J., Verbeek, M.M., Rieckmann, P., De Bruijn, C., Steinbusch, H.W.M., de Vente, J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - blood
alpha 1-Antichymotrypsin - blood
Alzheimer Disease - blood
Alzheimer Disease - physiopathology
Alzheimer’s disease
Analysis of Variance
Biological and medical sciences
Biomarkers - blood
Chi-Square Distribution
Cholesterol - blood
Cholesterol homeostasis
Combined marker analysis
Cysteine - blood
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Follow-Up Studies
Homocysteine
Humans
Hydroxycholesterols - blood
Inflammation
Interleukin-6 - blood
Logistic Models
Male
Medical sciences
Middle Aged
Neurodegenerative Diseases - blood
Neurology
Parkinson Disease - blood
Reference Values
Serum
Sterols - blood
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Summary:Alzheimer’s disease (AD) probably involves several pathobiochemical mechanisms and this may be reflected by changes in different serum components. The present study investigated whether the combined analysis of serum molecules related to different mechanisms improves the discrimination of AD patients from healthy controls. Serum of patients with AD was analyzed for a broad spectrum of marker molecules, including 11 inflammatory proteins, 12 sterol intermediates and phytosterols, 2 brain-specific proteins and 4 constituents involved in homocysteine homeostasis. The serum molecule concentrations were combined in a logistic regression model, using a forward stepwise inclusion mode. The results showed that the combination of interleukin-6 (IL-6) receptor, protein α1 fraction, cysteine and cholesterol concentrations improved the discrimination between AD patients and healthy controls compared to the single markers. In conclusion, the results of this study have shown that the complex pathology in AD is reflected in a pattern of altered serum concentrations of several marker molecules related to several pathobiochemical mechanisms.
ISSN:0197-4580
1558-1497
DOI:10.1016/S0197-4580(03)00005-8