Simple consensus procedures are effective and sufficient in secondary structure prediction

We have analyzed the performance of majority voting on minimal combination sets of three state‐of‐the‐art secondary structure prediction methods in order to obtain a consensus prediction. Using three large benchmark sets from the EVA server, our results show a significant improvement in the average...

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Bibliographic Details
Published in:Protein engineering 2003-07, Vol.16 (7), p.459-462
Main Authors: Albrecht, Mario, Tosatto, Silvio C.E., Lengauer, Thomas, Valle, Giorgio
Format: Article
Language:English
Subjects:
Computational Biology
consensus formation/protein structure prediction/secondary structure
Protein Structure, Secondary
Sequence Analysis, Protein
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Summary:We have analyzed the performance of majority voting on minimal combination sets of three state‐of‐the‐art secondary structure prediction methods in order to obtain a consensus prediction. Using three large benchmark sets from the EVA server, our results show a significant improvement in the average Q3 prediction accuracy of up to 1.5 percentage points by consensus formation. The application of an additional trivial filtering procedure for predicted secondary structure elements that are too short, does not significantly affect the prediction accuracy. Our analysis also provides valuable insight into the similarity of the results of the prediction methods that we combine as well as the higher confidence in consistently predicted secondary structure.
ISSN:0269-2139
1741-0126
1460-213X
1741-0134
DOI:10.1093/protein/gzg063