Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men

The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90‐min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurn...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2003-09, Vol.15 (9), p.851-854
Main Authors: Mullington, J. M., Chan, J. L., Van Dongen, H. P. A., Szuba, M. P., Samaras, J., Price, N. J., Meier-Ewert, H. K., Dinges, D. F., Mantzoros, C. S.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Circadian Rhythm
diurnal rhythm
Fundamental and applied biological sciences. Psychology
Humans
leptin
Leptin - blood
Male
Reference Values
Sleep - physiology
sleep deprivation
Sleep Deprivation - blood
Sleep Deprivation - physiopathology
Sleep. Vigilance
Space life sciences
Vertebrates: nervous system and sense organs
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Summary:The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90‐min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep. This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.
ISSN:0953-8194
1365-2826
DOI:10.1046/j.1365-2826.2003.01069.x