Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease

The major histocompatibility genes (MHC) have been associated with the genetic susceptibility to rheumatic heart disease (RHD). Results have been inconsistent and new genes located on the MHC region such as tumor necrosis factor (TNF-alpha) need to be analyzed. TNF-alpha polymorphisms (positions -23...

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Bibliographic Details
Published in:Journal of autoimmunity 2003-08, Vol.21 (1), p.59-63
Main Authors: Hernández-Pacheco, Guadalupe, Flores-Domı́nguez, Carmina, Rodrı́guez-Pérez, José Manuel, Pérez-Hernández, Nonanzit, Fragoso, José Manuel, Saul, Angela, Álvarez-León, Edith, Granados, Julio, Reyes, Pedro A, Vargas-Alarcón, Gilberto
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiopathies: etiologic forms (general aspects and miscellaneous)
Child
Child, Preschool
Female
Genetic Predisposition to Disease
Genetic susceptibility
Heart
Heart Valves - pathology
Humans
Major histocompatibility complex
Male
Medical sciences
Mexico
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic
Rheumatic heart disease
Rheumatic Heart Disease - genetics
Tumor necrosis factor-alpha
Tumor Necrosis Factor-alpha - genetics
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Summary:The major histocompatibility genes (MHC) have been associated with the genetic susceptibility to rheumatic heart disease (RHD). Results have been inconsistent and new genes located on the MHC region such as tumor necrosis factor (TNF-alpha) need to be analyzed. TNF-alpha polymorphisms (positions -238 and -308) were determined in 87 RHD Mexican Mestizo patients and 101 healthy controls. Patients were classified into mitral valve damage (MVD) and multivalvular lesion (MVL) categories. TNF-238 G allele and GG genotype were increased in patients when compared to healthy controls (pC=0.001, OR=14.1 and pC=0.003, OR=14.1, respectively). Also, decreased frequencies of TNF-238 A allele (pC=0.001) and AG genotype (pC=0.003) were found. TNF-308 polymorphism analysis showed increased frequencies of T2 (A) allele (pC
ISSN:0896-8411
1095-9157
DOI:10.1016/S0896-8411(03)00079-9