Hepatitis C virus and human immunodeficiency virus coinfection in Spain

Objective and methods: In a cross-sectional study, based on a cohort composed of HIV-infected patients of fifteen tertiary level institutions of Spain, the main data of the entire cohort are described, characteristics of patients with or without hepatitis C coinfection are compared, and the possible...

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Published in:The Journal of infection 2003-08, Vol.47 (2), p.117-124
Main Authors: Roca, Bernardino, Suarez, Ignacio, Gonzalez, Juan, Garrido, Myriam, de la Fuente, Belen, Teira, Ramon, Geijo, Paloma, Cosin, Jaime, Perez-Cortes, Salvador, Galindo, Maria Jose, Lozano, Fernando, Domingo, Pere, Viciana, Pompeyo, Ribera, Esteban, Vergara, Antonio, Sánchez, Trinitario
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chi-Square Distribution
Cohort
Coinfection
Cross-Sectional Studies
Female
Hepatitis C
Hepatitis C - complications
Hepatitis C - epidemiology
Hepatitis C virus
HIV
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Logistic Models
Male
Medical sciences
Middle Aged
Multicentre
Prevalence
Risk Factors
Spain - epidemiology
Statistics, Nonparametric
Viral diseases
Viral hepatitis
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Summary:Objective and methods: In a cross-sectional study, based on a cohort composed of HIV-infected patients of fifteen tertiary level institutions of Spain, the main data of the entire cohort are described, characteristics of patients with or without hepatitis C coinfection are compared, and the possible association of hepatitis C virus coinfection with socioeconomic, HIV-related, and hepatitis B-related variables is assessed. Results: A total of 4709 patients are studied. Median of age is 37 years, 78.3% are male. HIV risk behaviours are: parenteral drug use in 63.8% of patients, heterosexual in 22.3%, and homosexual in 10.8%. Serology of hepatitis C is positive in 69.2% of participants. The following variables are associated with increased prevalence of hepatitis C coinfection, both in univariate and in multivariate analysis: HIV risk behaviour, positive anti-HBs, longer time elapsed since HIV infection diagnosis, younger age, lower social status, lower CD4 cell count increase between nadir and last available result, and lower educational level (all P
ISSN:0163-4453
1532-2742
DOI:10.1016/S0163-4453(03)00067-7