Reproducibility of circulatory changes to head‐up tilt in healthy elderly subjects

Objective: to assess the reproducibility of the cardiovascular responses to head‐up tilt including cardiac output, stroke volume and peripheral resistance, in healthy older subjects using non‐invasive methods. Participants: twenty‐five healthy community‐dwelling volunteers with a mean age of 69±3 ye...

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Bibliographic Details
Published in:Age and ageing 2003-07, Vol.32 (4), p.375-381
Main Authors: Youde, Jane, Panerai, Ronney, Gillies, Clare, Potter, John
Format: Article
Language:English
Subjects:
Age factors in disease
Aged
Blood pressure
Cardiology
Cardiovascular response
Circulatory system
Diagnostic testing
Disease age factors
Elderly people
Electrocardiography
Female
Geriatrics
haemodynamic responses
head‐up tilt
Hemodynamics - physiology
Humans
Male
Middle Aged
Older people
Reproducibility
Reproducibility of Results
Stroke Volume - physiology
Tilt-Table Test
Time Factors
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Summary:Objective: to assess the reproducibility of the cardiovascular responses to head‐up tilt including cardiac output, stroke volume and peripheral resistance, in healthy older subjects using non‐invasive methods. Participants: twenty‐five healthy community‐dwelling volunteers with a mean age of 69±3 years. Methods: the subjects underwent head‐up tilt table testing on two occasions at an interval of 6 weeks. Pulse interval and blood pressure data were collected, on a beat‐to‐beat basis using a non‐invasive monitor (Finapres, Ohmeda), during 70° head‐up tilt table testing and stored for analysis. Analysis: the pulse interval and blood pressure data for the group were pooled and the relative changes in cardiac output, stroke volume and peripheral resistance were calculated using pulse contour analysis. Results: the systolic blood pressure, pulse interval, cardiac output and stroke volume fell immediately after tilt with a rise in peripheral resistance. These responses were similar, though the baseline systolic blood pressure levels were lower at the second visit (P=0.06). Conclusion: these non‐invasively assessed cardiovascular responses to head‐up tilt in healthy older subjects show little variation between visits. The reproducibility of the responses in subjects with syncope and autonomic failure warrants further investigation.
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/32.4.375