Maternal immunization with pneumococcal polysaccharide vaccine in the Philippines

A randomized, controlled study was conducted to evaluate the immunogenicity and reactogenicity of the 23-valent pneumococcal (Pnc) polysaccharide (PS) vaccine among pregnant women and to ascertain the transfer of anti-Pnc antibody (Ab) from mother to infant. One hundred and sixty women received eith...

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Bibliographic Details
Published in:Vaccine 2003-07, Vol.21 (24), p.3451-3454
Main Authors: Quiambao, B.P., Nohynek, H., Käyhty, H., Ollgren, J., Gozum, L., Gepanayao, C.P., Soriano, V., Mäkela, P.H.
Format: Article
Language:English
Subjects:
Adult
Age
Antibodies
Antibodies, Bacterial - analysis
Antibodies, Bacterial - biosynthesis
Babies
Bacterial diseases
Bacteriology
Biological and medical sciences
Confidence intervals
Data analysis
Disease
Female
Fetal Blood - immunology
Fundamental and applied biological sciences. Psychology
Health facilities
Human bacterial diseases
Humans
Immunization Programs
Infant, Newborn
Infectious diseases
Maternal immunization
Medical sciences
Meningitis
Microbiology
Mortality
Mothers
Philippines
Pneumococcal Vaccines - adverse effects
Pneumococcal Vaccines - immunology
Pneumococcus
Pregnancy
Pregnancy Trimester, Third - immunology
Serotyping
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcus infections
Streptococcus pneumoniae - immunology
Studies
Tropical medicine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Womens health
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Description
Summary:A randomized, controlled study was conducted to evaluate the immunogenicity and reactogenicity of the 23-valent pneumococcal (Pnc) polysaccharide (PS) vaccine among pregnant women and to ascertain the transfer of anti-Pnc antibody (Ab) from mother to infant. One hundred and sixty women received either one dose of Pnc PS vaccine, Haemophilus influenzae type b conjugate vaccine and tetanus toxoid (TT) (Pnc vaccine group, N=106) or TT only (control group, N=54). Sera were obtained from all mothers prior to vaccination and 4 weeks after from the vaccinated group. Cord blood was obtained in 75% of deliveries. Anti-Pnc Ab for serotypes 1, 5, 6B, 14, 18C and 19F was determined using enzyme immunoassay. The Pnc vaccine and control groups were comparable in terms of age, parity, gravidity, prior doses of TT, and pre-vaccination geometric mean concentration (GMC in μg/ml) of anti-Pnc Ab. Between 66 and 87% of the mothers had type-specific Ab prior to vaccination. There was a significant rise in anti-Pnc Ab (varying from 3.3- to 9.1-fold for the individual serotypes) between the pre and post-vaccination samples. Adverse reactions were mild and required no treatment. The level of anti-Pnc Ab in cord blood was significantly lower in the control group compared to the Pnc vaccine group. Vaccination of pregnant women with Pnc Ps vaccine induces good immune response and Ab can be transferred to their infants via cord blood thus providing enhanced protection.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00349-9