Evidence of recombination in natural populations of hepatitis A virus

Genetic analysis of selected genome regions of hepatitis A virus (HAV) suggested that distinct genotypes of HAV could be found in different geographical regions. At least seven HAV genotypes have been identified all over the world, including four human genotypes (I, II, III, and VII) and three simia...

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Published in:Virology (New York, N.Y.) N.Y.), 2003-06, Vol.311 (1), p.51-59
Main Authors: Costa-Mattioli, Mauro, Ferré, Virginie, Casane, Didier, Perez-Bercoff, Raoul, Coste-Burel, Marianne, Imbert-Marcille, Berthe-Marie, Andre, Elisabeth Claude Monique, Bressollette-Bodin, Celine, Billaudel, Sylviane, Cristina, Juan
Format: Article
Language:English
Subjects:
Capsid Proteins - genetics
Crossing Over, Genetic
Genetic Variation
Genome, Viral
Hepatitis A Virus, Human - genetics
Humans
Molecular Sequence Data
Morocco
Phylogeny
Sequence Analysis, Protein
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Summary:Genetic analysis of selected genome regions of hepatitis A virus (HAV) suggested that distinct genotypes of HAV could be found in different geographical regions. At least seven HAV genotypes have been identified all over the world, including four human genotypes (I, II, III, and VII) and three simian strains (IV, V, and VI). Phylogenetic analysis using full-length VP1 sequences revealed that human strain 9F94 has a close genetic relation with strain SLF-88 (sub-genotype VII). Nevertheless, the same analysis using full-length VP2 or VP3 sequences revealed that strain 9F94 has a close genetic relation with strain MBB (sub-genotype IB). To test the possibility of genetic recombination, phylogenetic studies were carried out, revealing that a crossing over had taken place in the VP1 capsid protein. These findings indicate that capsid-recombination can play a significant role in shaping the genetic diversity of HAV and, as such, can have important implications for its evolution, biology, and control.
ISSN:0042-6822
1096-0341
DOI:10.1016/S0042-6822(03)00109-0