Towards large-scale synthetic applications of Baeyer-Villiger monooxygenases

Biocatalysis is coming of age, with an increasing number of reactions being scaled-up and developed. The diversity of reactions is also increasing and oxidation reactions have recently been considered for scale-up to commercial processes. One important chemical conversion, which is difficult to achi...

Full description

Saved in:
Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2003-07, Vol.21 (7), p.318-323
Main Authors: Alphand, Veronique, Carrea, Giacomo, Wohlgemuth, Roland, Furstoss, Roland, Woodley, John M.
Format: Article
Language:English
Subjects:
Biocatalysts
Biological and medical sciences
Bioreactors - microbiology
Biotechnology
Catalysis
Chemical Industry - methods
Chemical industry. Chemical engineering
Enzymes
esters
Fundamental and applied biological sciences. Psychology
Industrial applications and implications. Economical aspects
Ketones - chemistry
Ketones - metabolism
ketosteroid monooxygenase
lactones
Lactones - chemistry
Lactones - metabolism
Mixed Function Oxygenases - chemistry
Mixed Function Oxygenases - genetics
Mixed Function Oxygenases - isolation & purification
Mixed Function Oxygenases - metabolism
Organic chemistry
Oxidation
Oxidation-Reduction
Oxygenases - chemistry
Oxygenases - genetics
Oxygenases - isolation & purification
Oxygenases - metabolism
Pilot Projects
Protein Engineering - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biocatalysis is coming of age, with an increasing number of reactions being scaled-up and developed. The diversity of reactions is also increasing and oxidation reactions have recently been considered for scale-up to commercial processes. One important chemical conversion, which is difficult to achieve enantio- or enantiotopo- selectively, is the Baeyer-Villiger (BV) oxidation of ketones. Using cyclohexanone monooxygenase to catalyse the reaction produces optically pure esters and lactones with exquisite enantiomeric excess values. Recently, these enzymes and their many applications in synthetic chemistry have been explored. The scale-up of these conversions has been examined with the idea of implementing the first commercial Baeyer-Villiger monooxygenase-based process. Here, we review the state-of-the-art situation for the scale-up and exploitation of these enzymes.
ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(03)00144-6