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Relation of Recurrence of Atrial Fibrillation After Successful Cardioversion to Renal Function

Angiotensin II exerts proinflammatory effects leading to atrial fibrosis that is associated with persistence of atrial fibrillation (AF). Renal function plays a major role in activation of the renin–angiotensin–aldosterone system. We examined whether the level of impaired renal function, defined by...

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Bibliographic Details
Published in:The American journal of cardiology 2010-02, Vol.105 (3), p.368-372
Main Authors: Schmidt, Martin, MD, Rieber, Johannes, MD, Daccarett, Marcos, MD, MSc, Marschang, Harald, MD, Sinha, Anil-Martin, MD, Biggar, Patrick, MD, Jung, Philip, MD, Ketteler, Markus, MD, Brachmann, Johannes, MD, Rittger, Harald, MD
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Language:English
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Summary:Angiotensin II exerts proinflammatory effects leading to atrial fibrosis that is associated with persistence of atrial fibrillation (AF). Renal function plays a major role in activation of the renin–angiotensin–aldosterone system. We examined whether the level of impaired renal function, defined by glomerular filtration rate (GFR), would influence the maintenance of sinus rhythm after successful external electric cardioversion (ECV). One hundred two consecutive patients with persistent AF underwent successful ECV. Patients were prospectively followed for recurrence of AF by telephone interviews, Holter electrocardiograms, and electrocardiograms sent by primary care providers. Repeated GFR assays were performed before and 1 month after ECV. Patients were divided into 4 groups according to baseline GFR (I >90 ml/min, II 60 to 90 ml/min, III 30 to 59 ml/min, IV
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2009.09.037