Effects of calcium supplementation on uteroplacental and fetoplacental blood flow in low-calcium-intake mothers: a randomized controlled trial

Objective We postulated that calcium supplementation of calcium-deficient pregnant women would lower vascular resistance in uteroplacental and fetoplacental circulations. Study Design Pulsatility index (PI) and resistance index (RI) (uterine and umbilical arteries) and presence of bilateral uterine...

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Published in:	American journal of obstetrics and gynecology 2010, Vol.202 (1), p.45.e1-45.e9
Main Authors:	Carroli, Guillermo, MD, Merialdi, Mario, MD, PhD, Wojdyla, Daniel, PhD, Abalos, Edgardo, MD, Campodonico, Liana, MSc, Yao, Shih-Ern, MBBS, Gonzalez, Rogelio, MD, Deter, Russell, MD, Lindheimer, Marshall, MD, Van Look, Paul, MD, PhD
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Biological and medical sciences calcium supplementation Calcium, Dietary - administration & dosage Dietary Supplements Diseases of the digestive system Doppler velocimetry Female Fetus - physiology Gynecology. Andrology. Obstetrics Humans Laser-Doppler Flowmetry Medical sciences Obstetrics and Gynecology Placenta - blood supply Placenta - diagnostic imaging preeclampsia Pregnancy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Regional Blood Flow - drug effects Ultrasonography, Doppler Ultrasonography, Prenatal Uterus - blood supply Uterus - diagnostic imaging Vascular Resistance - drug effects Vascular Resistance - physiology Vasodilation - drug effects Vasodilation - radiation effects Young Adult
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Summary:	Objective We postulated that calcium supplementation of calcium-deficient pregnant women would lower vascular resistance in uteroplacental and fetoplacental circulations. Study Design Pulsatility index (PI) and resistance index (RI) (uterine and umbilical arteries) and presence of bilateral uterine artery diastolic notching were assessed by Doppler ultrasound between 20-36 weeks' gestation in 510 healthy, nulliparous Argentinean women with deficient calcium intake in a randomized, placebo-controlled, double-blinded trial. Results Average umbilical and uterine artery RI and PI tended to be lower in the supplemented group at each study week. Differences became statistically significant for umbilical artery RI and PI from 32 and 36 weeks, respectively. Estimated probabilities of bilateral uterine artery diastolic notching trended toward lower values in calcium-supplemented women. Conclusion Calcium supplementation of pregnant women with deficient calcium intake may affect uteroplacental and fetoplacental blood flow by preserving the vasodilation of normal gestation.
ISSN:	0002-9378 1097-6868