Parental occupational exposure to organic solvents and anencephaly in Mexico

Objective:To assess the relationship between parental occupational exposure to organic solvents, and the risk of anencephaly in Mexico.Methods:A case-control study was conducted based on the registers of the Epidemiological Surveillance System for Neural Tube Defects in Mexico; 151 cases of anenceph...

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Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2010-01, Vol.67 (1), p.32-37
Main Authors: AGUILAR-GARDUNO, C, LACASANA, M, BLANCO-MUNOZ, J, BORJA-ABURTO, V. Hugo, GARCIA, A. M
Format: Article
Language:English
Subjects:
Adult
Anencephaly
Anencephaly - epidemiology
Biological and medical sciences
Birth defects
Case-Control Studies
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical hazards
Children
Congenital defects
Embryology: invertebrates and vertebrates. Teratology
Etiology
Fathers
Female
Folic acid
Fundamental and applied biological sciences. Psychology
Humans
Hydrocarbons
Male
Malformations of the nervous system
Maternal Exposure - statistics & numerical data
Medical sciences
Mexico - epidemiology
Molecular weight
Mothers
Neural tube defects
Neurology
Occupational exposure
Occupational Exposure - adverse effects
Occupational Exposure - statistics & numerical data
Organic solvents
Parents
Paternal Exposure - statistics & numerical data
Pregnancy
Public health
Regression analysis
Reproductive history
Risk Factors
Solvents
Solvents - toxicity
Spina bifida
Teratology. Teratogens
Toxicology
Vitamins
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Summary:Objective:To assess the relationship between parental occupational exposure to organic solvents, and the risk of anencephaly in Mexico.Methods:A case-control study was conducted based on the registers of the Epidemiological Surveillance System for Neural Tube Defects in Mexico; 151 cases of anencephaly of ⩾20 weeks’ gestation were included. A control, born alive and without any apparent congenital malformations at birth, was selected for each case in the same maternity service in which the case was born. Information on occupational exposures, lifestyle habits, reproductive history, use of medicines, supplementation with multivitamins and folic acid, was obtained by a general questionnaire; a food frequency questionnaire was also applied to obtain information of daily intake of folate and other B vitamins. Occupational exposure to organic solvents was based on job title as a proxy for exposure and analysed considering two critical periods around conception.Results:In logistic regression analysis, the odds of having a child with anencephaly was higher if the mother or the father was occupationally exposed to organic solvents during the periconceptional period, or when both parents or at least one of them were occupationally exposed during this period with an adjusted odds ratio of 2.97 (95% CI 1.36 to 6.52).Conclusions:The results support the hypothesis that both maternal and paternal occupational exposure to organic solvents can increase the probability of having a child with anencephaly.
ISSN:1351-0711
1470-7926
DOI:10.1136/oem.2008.044743