Twelve‐hour reproducibility of retinal and optic nerve blood flow parameters in healthy individuals

. Purpose:  The aim of the present study was to investigate the reproducibility and potential diurnal variation of optic nerve head and retinal blood flow parameters in healthy individuals over a period of 12 hr. Methods:  We measured optic nerve head and retinal blood flow parameters in 16 healthy...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2009-12, Vol.87 (8), p.875-880
Main Authors: Luksch, Alexandra, Lasta, Michael, Polak, Kaija, Fuchsjäger‐Mayrl, Gabriele, Polska, Elzbieta, Garhöfer, Gerhard, Schmetterer, Leopold
Format: Article
Language:English
Subjects:
Adult
Circadian Rhythm
diurnal variation
human
Humans
Male
Optic Nerve - blood supply
optic nerve head blood flow
Reference Values
Regional Blood Flow
reproducibility
Reproducibility of Results
retinal blood flow
Retinal Vessels - physiology
Time Factors
validity
Young Adult
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Summary:. Purpose:  The aim of the present study was to investigate the reproducibility and potential diurnal variation of optic nerve head and retinal blood flow parameters in healthy individuals over a period of 12 hr. Methods:  We measured optic nerve head and retinal blood flow parameters in 16 healthy male non‐smoking individuals at five time‐points during the day (08:00, 11:00, 14:00, 17:00 and 20:00 hr). Outcome parameters were perimacular white blood cell flux (as assessed with the blue field entoptic technique), blood velocities in retinal veins (as assessed with bi‐directional laser Doppler velocimetry), retinal arterial and venous diameters (as assessed with the retinal vessel analyser), optic nerve head blood flow, volume and velocity (as assessed with single point and scanning laser Doppler flowmetry) and blood velocities in the central retinal artery (as assessed with colour Doppler imaging). The coefficient of variation and the maximum change from baseline in an individual were calculated for each outcome parameter. Results:  No diurnal variation in optic nerve head or retinal blood flow was observed with any of the techniques employed. Coefficients of variation were between 1.6% and 18.5% for all outcome parameters. The maximum change from baseline in an individual was much higher, ranging from 3.7% to 78.2%. Conclusion:  Our data indicate that in healthy individuals the selected techniques provide adequate reproducibility to be used in clinical studies. However, in patients with eye diseases and reduced vision the reproducibility may be considerably worse.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2008.01388.x