Long-term protection provided by hepatitis B vaccine and need for booster dose: A meta-analysis

Abstract The duration of protection provided by hepatitis B vaccine is still unknown but can be estimated through long-term follow-up studies. Electronic databases and conference databases to December 2008 were searched. Reference lists of articles were screened and the studies authors and manufactu...

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Bibliographic Details
Published in:Vaccine 2010-01, Vol.28 (3), p.623-631
Main Authors: Poorolajal, Jalal, Mahmoodi, Mahmood, Majdzadeh, Reza, Nasseri-Moghaddam, Siavosh, Haghdoost, AliAkbar, Fotouhi, Akbar
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens
Applied microbiology
Bias
Biological and medical sciences
Booster
Clinical trials
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis B - prevention & control
Hepatitis B infection
Hepatitis B vaccine
Hepatitis B Vaccines - immunology
Hepatitis B virus
Human viral diseases
Humans
Immunization, Secondary
Infections
Infectious diseases
Medical sciences
Meta-analysis
Microbiology
Studies
Time Factors
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral hepatitis
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Summary:Abstract The duration of protection provided by hepatitis B vaccine is still unknown but can be estimated through long-term follow-up studies. Electronic databases and conference databases to December 2008 were searched. Reference lists of articles were screened and the studies authors and manufacturers were contacted for additional unpublished references. Randomized clinical trials and prospective cohort studies addressing the long-term protective effect of hepatitis B vaccine were included in this meta-analysis. We assessed 42 separate cohorts involving overall 11,090 subjects; 34 cohorts involving 9356 subjects were included in the final meta-analysis. Results indicate that the overall cumulative incidence of HBV breakthrough infection 5–20 years post-primary vaccination was 0.007 [95% CI: 0.005 to 0.010] with a variation among studies from 0 to 0.094. Available data do not allow us to exclude an increased risk for infection with time since vaccination. We conclude that the protection provided by three or four doses of monovalent HB vaccine persists for at least two decades in the great majority of immunocompetent individuals. Additional studies are needed for assessing vaccine efficacy for longer periods of time and the need of booster doses in different subgroups of population.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.10.068