Pattern of Disease Onset, Diagnostic Delay, and Clinical Features in Juvenile Onset and Adult Onset Ankylosing Spondylitis

Objective. To assess the frequency of juvenile onset ankylosing spondylitis (JOAS) in Turkish patients with AS and to compare with adult onset AS (AOAS) in a cross-sectional study design. Methods. A total of 322 patients were recruited from the joint database of 5 university hospitals in eastern Tur...

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Published in:Journal of rheumatology 2009-12, Vol.36 (12), p.2830-2833
Main Authors: OZGOCMEN, Salih, ARDICOGLU, Ozge, CEVIK, Remzi, ERDAL, Akin, ERSOY, Yuksel, SARAC, Aysegul J, TEKEOGLU, Ibrahim, UGUR, Mahir, NAS, Kemal, SENEL, Kazim, ULUSOY, Hasan, KAMANLI, Ayhan, KAYA, Arzu, DURMUS, Bekir, YILDIRIM, Kadir, BAYSAL, Ozlem, GUR, Ali, KARATAY, Saliha, ALTAY, Zuhal
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Aged
Biological and medical sciences
Cross-Sectional Studies
Databases, Factual
Diseases of the osteoarticular system
Diseases of the spine
Female
Humans
Inflammatory joint diseases
Male
Medical sciences
Middle Aged
Spondylitis, Ankylosing - diagnosis
Spondylitis, Ankylosing - epidemiology
Spondylitis, Ankylosing - physiopathology
Turkey
Young Adult
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Summary:Objective. To assess the frequency of juvenile onset ankylosing spondylitis (JOAS) in Turkish patients with AS and to compare with adult onset AS (AOAS) in a cross-sectional study design. Methods. A total of 322 patients were recruited from the joint database of 5 university hospitals in eastern Turkey. Results. Patients with JOAS (n = 43, 13.4%) had significantly longer diagnostic delay (9.21 vs 5.08 yrs), less severe axial involvement and more prevalent uveitis (OR 2.92, 95% CI 1.25–6.79), and peripheral involvement at onset (OR 3.25, 95% CI 1.51–6.98, adjusted for current age; and OR 2.26, 95% CI 1.07–4.76, adjusted for disease duration). Patients with AOAS had higher radiographic scores and more restricted clinimetrics but similar functional limitations and quality of life. Conclusion. JOAS and AOAS had distinctive courses and Turkish patients with AS had similar features compared to other Caucasian patient populations.
ISSN:0315-162X
1499-2752
DOI:10.3899/jrheum.090435