Multimodality Imaging of Carotid Artery Plaques 18F-Fluoro-2-Deoxyglucose Positron Emission Tomography, Computed Tomography, and Magnetic Resonance Imaging

This study's objective was to compare (18)F-fluoro-2-deoxyglucose positron emission tomography ((18)F-FDG PET), CT, and MRI of carotid plaque assessment. Fifty patients with symptomatic carotid atherosclerosis underwent (18)F-FDG PET/CT and MRI. Correlations and agreement between imaging findin...

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Bibliographic Details
Published in:Stroke (1970) 2009-12, Vol.40 (12), p.3718-3724
Main Authors: KWEE, Robert M, TEULE, Gerrit J. J, HOFMAN, Paul A. M, VAN ENGELSHOVEN, Jos M. A, WILDBERGER, Joachim E, KOOI, M. Eline, VAN OOSTENBRUGGE, Robert J, MESS, Werner H, PRINS, Martin H, VAN DER GEEST, Rob J, TER BERG, Johannes W. M, FRANKE, Cees L, KORTEN, Arthur G. G. C, MEEMS, Bé J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Calcinosis - diagnostic imaging
Calcinosis - pathology
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Arteries - pathology
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - pathology
Female
Fibrosis - diagnostic imaging
Fibrosis - pathology
Fluorodeoxyglucose F18
Humans
Image Processing, Computer-Assisted - methods
Lipids - analysis
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - statistics & numerical data
Male
Medical sciences
Middle Aged
Neurology
Positron-Emission Tomography - methods
Positron-Emission Tomography - statistics & numerical data
Predictive Value of Tests
Sensitivity and Specificity
Statistics as Topic
Tomography, X-Ray Computed - methods
Tomography, X-Ray Computed - statistics & numerical data
Vascular diseases and vascular malformations of the nervous system
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Summary:This study's objective was to compare (18)F-fluoro-2-deoxyglucose positron emission tomography ((18)F-FDG PET), CT, and MRI of carotid plaque assessment. Fifty patients with symptomatic carotid atherosclerosis underwent (18)F-FDG PET/CT and MRI. Correlations and agreement between imaging findings were assessed by Spearman and Pearson rank correlation tests, t tests, and Bland-Altman plots. Spearman rho between plaque (18)F-FDG standard uptake values and CT/MRI findings varied from -0.088 to 0.385. Maximum standard uptake value was significantly larger in plaques with intraplaque hemorrhage (1.56 vs 1.47; P=0.032). Standard uptake values did not significantly differ between plaques with an intact and thick fibrous cap and plaques with a thin or ruptured fibrous cap on MRI. (1.21 vs 1.23; P=0.323; and 1.45 vs 1.54; P=0.727). Pearson rho between CT and MRI measurements varied from 0.554 to 0.794 (P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.109.564088