Mast cell stabilization and antihistaminic potentials of Curculigo orchioides rhizomes

Inhibition of histamine upon exposure to allergen like compound 48/80 is considered to be the promising strategy for screening of the drugs used in allergic disorders. The effect of alcoholic extract of rhizomes of Curculigo orchioides (COR) on inhibition of histamine release upon degranulation was...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2009-12, Vol.126 (3), p.434-436
Main Authors: Venkatesh, P., Mukherjee, Pulok K., N, Satheesh Kumar, Nema, Neelesh K., Bandyopadhyay, A., Fukui, Hiroyuki, Mizuguchi, Hiroyuki
Format: Article
Language:English
Subjects:
Amaryllidaceae
animal models
Animals
antiallergenic properties
antihistamines
Biological and medical sciences
Cell Degranulation - drug effects
cell lines
Compound 48/80
cultured cells
Curculigo - chemistry
Curculigo orchioides
degranulation
General pharmacology
histamine
Histamine Antagonists - pharmacology
histamine release
Histamine Release - drug effects
immediate hypersensitivity
Indian traditional medicine
Male
mast cell degranulation
Mast cell stabilization
mast cells
Mast Cells - drug effects
Mast Cells - metabolism
Medical sciences
medicinal plants
medicinal properties
Mice
mortality
p-Methoxy-N-methylphenethylamine - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
plant extracts
Plant Extracts - pharmacology
rhizomes
Systemic anaphylaxis
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Summary:Inhibition of histamine upon exposure to allergen like compound 48/80 is considered to be the promising strategy for screening of the drugs used in allergic disorders. The effect of alcoholic extract of rhizomes of Curculigo orchioides (COR) on inhibition of histamine release upon degranulation was studied. COR at dose of 400 mg/kg inhibited both the degranulation of mast cells (60.96 ± 1.96%) and the release of histamine in blood (63.58 ± 1.8%) and thus supports the claims of its use as antihistaminic in the traditional Indian systems of medicine. To investigate the mast cell stabilization and antihistaminic activities of the rhizomes of Curculigo orchioides (COR). Extract of Curculigo orchioides Gaertn. (Fam. Amaryllidaceae) has been reported to possess immunostimulant, and anti-inflammatory potentials. In Indian traditional system of medicine it is also used as anti-asthmatic and anti-inflammatory. Estimation of histamine release is key parameter for evaluating any target for its anti-allergic potential. The stabilization potential of the alcoholic extract of COR (100–400 mg/kg) against mast cell degranulation was studied on isolated mice peritoneal mast cells. The antihistaminic activity was performed by determining the mortality rate of mice upon exposure to compound 48/80 and effect on inhibition of histamine release upon degranulation. The raised number of intact mast cells intimates that the COR stabilized the mast cell degranulation (60.96 ± 1.96%) and percentage antihistaminic potential of the extract (63.58 ± 1.8 inhibition at dose of 400 mg/kg) and it virtues further work towards the isolation of phytoconstituents from this plant. This finding provides evidence that COR inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2009.09.019