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Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals
Brain-derived neurotrophic factor (BDNF) has been shown to regulate neuronal development and plasticity and plays a role in learning and memory. Moreover, it is well established that BDNF plays a role in the hypothalamic pathway that controls body weight and energy homeostasis. Recent evidence ident...
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Published in: | Experimental physiology 2009-12, Vol.94 (12), p.1153-1160 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Request full text |
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Summary: | Brain-derived neurotrophic factor (BDNF) has been shown to regulate neuronal development and plasticity and plays a role in
learning and memory. Moreover, it is well established that BDNF plays a role in the hypothalamic pathway that controls body
weight and energy homeostasis. Recent evidence identifies BDNF as a player not only in central metabolism, but also in regulating
energy metabolism in peripheral organs. Low levels of BDNF are found in patients with neurodegenerative diseases, including
Alzheimer's disease and major depression. In addition, BDNF levels are low in obesity and independently so in patients with
type 2 diabetes. Brain-derived neurotrophic factor is expressed in non-neurogenic tissues, including skeletal muscle, and
exercise increases BDNF levels not only in the brain and in plasma, but in skeletal muscle as well. Brain-derived neurotrophic
factor mRNA and protein expression was increased in muscle cells that were electrically stimulated, and BDNF increased phosphorylation
of AMP-activated protein kinase (AMPK) and acetyl coenzyme A carboxylase-beta (ACCβ) and enhanced fatty oxidation both in vitro and ex vivo . These data identify BDNF as a contraction-inducible protein in skeletal muscle that is capable of enhancing lipid oxidation
in skeletal muscle via activation of AMPK. Thus, BDNF appears to play a role both in neurobiology and in central as well as
peripheral metabolism. The finding of low BDNF levels both in neurodegenerative diseases and in type 2 diabetes may explain
the clustering of these diseases. Brain-derived neurotrophic factor is likely to mediate some of the beneficial effects of
exercise with regard to protection against dementia and type 2 diabetes. |
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ISSN: | 0958-0670 1469-445X |
DOI: | 10.1113/expphysiol.2009.048561 |