Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program

Abstract Primary neuroendocrine tumors of the gallbladder (GB) and extrahepatic biliary ducts (EHBDs) include carcinoid tumors and small-cell carcinomas (SCCs). They are uncommon, and therefore, little is known about their demographics and clinical course. From National Cancer Institute's Surve...

Full description

Saved in:
Bibliographic Details
Published in:Annals of diagnostic pathology 2009-12, Vol.13 (6), p.378-383
Main Authors: Albores-Saavedra, Jorge, MD, Batich, Kristen, BA, Hossain, Sarah, MBBS, Henson, Donald E., MD, Schwartz, Arnold M., MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Bile Duct Neoplasms - epidemiology
Bile Duct Neoplasms - pathology
Bile Ducts, Extrahepatic - pathology
Carcinoid
Carcinoid Tumor - epidemiology
Carcinoid Tumor - pathology
Carcinoma, Small Cell - epidemiology
Carcinoma, Small Cell - pathology
Extrahepatic bile duct
Female
Gallbladder
Gallbladder Neoplasms - epidemiology
Gallbladder Neoplasms - pathology
Humans
Male
Middle Aged
Neuroendocrine carcinoma
Pathology
SEER Program
Small-cell carcinoma
Survival Rate
United States - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Primary neuroendocrine tumors of the gallbladder (GB) and extrahepatic biliary ducts (EHBDs) include carcinoid tumors and small-cell carcinomas (SCCs). They are uncommon, and therefore, little is known about their demographics and clinical course. From National Cancer Institute's Surveillance, Epidemiology, and End Results program (1973-2005), we analyzed the demographics and 10-year relative survival rates of carcinoids and SCCs of the GB and EHBD according to histologic type and stage. There were 119 cases of carcinoid tumors and 54 cases of SCCs in the GB. There were 31 carcinoid tumors and 17 SCCs in the EHBD. The female/male ratios of carcinoids in the GB and EHBD were 2.4 and 1.6, respectively. The ratios for SCC in the GB and EHBD were 2.2 and 1.1, respectively. For the GB, the mean age of diagnosis for carcinoids was 64.5, and for SCC, it was 67.5. For the EHBD, the mean age was 58.2 for carcinoids and 68.4 for SCC. The 10-year survival rates were 36% for carcinoid tumors of the GB and 80% for carcinoid tumors of the EHBD. For SCC, the 10-year survival was 0% in the GB and EHBD. Carcinoid tumors and SCC of the extrahepatic biliary tree are uncommon neoplasms that differ in their demographics and biologic behavior, supporting the distinction of these 2 histopathologic types. Therefore, these tumors should be separately classified and not included in the single generic group of neuroendocrine carcinoma.
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2009.08.002