Increased expression of decorin during the regeneration stage of mdx mouse

Satellite cells exist in postnatal muscle tissue and constitute the main source of muscle precursor cells for growth and repair. These cells carry out important roles for skeletal muscle formation postnatally during growth of muscle mass as well as damage-induced regenerative processes. Muscle regen...

Full description

Saved in:
Bibliographic Details
Published in:Anatomical science international 2009-12, Vol.84 (4), p.305-311
Main Authors: Abe, Shinichi, Hirose, Daiki, Kado, Syotaro, Iwanuma, Osamu, Saka, Hideki, Yanagisawa, Nobuaki, Ide, Yoshinobu
Format: Article
Language:English
Subjects:
Anatomy
Animal Anatomy
Animal Physiology
Animals
Cell Biology
Cells
Decorin
Extracellular Matrix Proteins - metabolism
Histology
Human Physiology
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Mice
Mice, Inbred C57BL
Morphology
Muscle, Skeletal - metabolism
Muscular Dystrophy, Animal - metabolism
Musculoskeletal system
Myostatin - metabolism
Neuromuscular diseases
Neurosciences
Original Article
Proteins
Proteoglycans - metabolism
Regeneration
Ribonucleic acid
RNA
RNA, Messenger - metabolism
Rodents
Tissues
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Satellite cells exist in postnatal muscle tissue and constitute the main source of muscle precursor cells for growth and repair. These cells carry out important roles for skeletal muscle formation postnatally during growth of muscle mass as well as damage-induced regenerative processes. Muscle regeneration supports muscle function in aging and has a role in the functional impairment caused by progressive neuromuscular diseases. Major substances controlling this process are growth factors and extracellular matrix. Myostatin, a member of TGF-β family, was mainly expressed in muscle tissue. Decorin, a member of the small leucine-rich proteoglycan gene family, is composed of a core protein and a dermatan/chondroitin sulfate chain. Recent studies have shown that decorin enhanced the proliferation and differentiation of myogenic cells by suppressing myostatin activity. Thus, decorin appears to be a new molecule in the myostatin signaling pathway and a promising target for treatment of progressive neuromuscular diseases. Therefore, in this study, we examined the localization of decorin as well as myostatin in a muscular dystrophy model in mdx mice and B10 Scott Snells mice as a control to elucidate the differences between decorin and myostatin messages as well as protein distribution. This study revealed increased expression of decorin protein as well as mRNA at the regenerative stage of mdx mice compared to early stages, while only weak expression of decorin was detected in the control mice. Our study contributes to identifying the relationship between decorin and myostatin as well as the development of a therapeutic strategy for progressive neuromuscular diseases.
ISSN:1447-6959
1447-073X
DOI:10.1007/s12565-009-0039-9