Systemic drug-related intertriginous and flexural exanthema (SDRIFE)

A 72-year-old man with a history of metastatic melanoma presented with a two-day history of erythematous and edematous plaques, with scattered bullae on the neck, chest, axillae, and inguinal and gluteal folds, which began five days after infusion of an experimental drug. The clinical and histopatho...

Full description

Saved in:
Bibliographic Details
Published in:Dermatology online journal 2009-08, Vol.15 (8), p.3-3
Main Authors: Elmariah, Sarina B, Cheung, Wang, Wang, Nadia, Kamino, Hideko, Pomeranz, Miriam K
Format: Article
Language:English
Subjects:
Aged
Antibodies, Monoclonal - adverse effects
Drug Eruptions - etiology
Drug Eruptions - pathology
Exanthema - chemically induced
Exanthema - pathology
Humans
Male
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 72-year-old man with a history of metastatic melanoma presented with a two-day history of erythematous and edematous plaques, with scattered bullae on the neck, chest, axillae, and inguinal and gluteal folds, which began five days after infusion of an experimental drug. The clinical and histopathologic findings were consistent with systemic drug-related intertriginous and flexural exanthema (SDRIFE), which is an uncommon drug reaction that results in symmetric erythema that affects the buttocks, groin, and/or thighs as well other flexural folds. The clinical manifestations of SDRIFE are highly characteristic and include distinctive primary cutaneous lesions with a specific distribution and course; however, heterogeneity exists with respect to histopathologic features, skin test results, and in vitro investigations. The exact mechanism of SDRIFE remains unknown but is thought to result from a type IV delayed hypersensitivity immune response. Treatment is symptomatic and includes topical or oral glucocorticoids.
ISSN:1087-2108
1087-2108
DOI:10.5070/D32WS5H2S0