The early postnatal development of salivary antibody and immunoglobulin response in children orally colonized with a nonpathogenic, probiotic strain of E. coli

The development of levels of secretory immunoglobulins (SIgs) in newborns' saliva was examined under physiological conditions and after artificial colonization with nonpathogenic, probiotic bacterial strain E. coli O83. Higher levels of secretory immunoglobulin M (SIgM) and secretory immunoglob...

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Bibliographic Details
Published in:Folia microbiologica 2003, Vol.48 (2), p.281-287
Main Authors: VANCIKOVA, Z, LODINOVA-ZADNIKOVA, R, RADL, J, TLASKALOVA-HOGENOVA, H
Format: Article
Language:English
Subjects:
Antibodies - analysis
Biological and medical sciences
Bottle Feeding
Breast Feeding
Escherichia coli
Escherichia coli - growth & development
Escherichia coli - immunology
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin A, Secretory - analysis
Immunoglobulins - analysis
Infant
Infant, Newborn
Male
Microbiology
Probiotics
Saliva - immunology
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Summary:The development of levels of secretory immunoglobulins (SIgs) in newborns' saliva was examined under physiological conditions and after artificial colonization with nonpathogenic, probiotic bacterial strain E. coli O83. Higher levels of secretory immunoglobulin M (SIgM) and secretory immunoglobulin A (SIgA) were detected in the saliva of breast-fed children when compared with those of bottle-fed infants. SIgM was found earlier than SIgA, the levels of both SIgM and SIgA decreased after weaning. Breastfeeding actively stimulates local immunity on mucosal membranes of newborn infants. Early mucosal colonization with nonpathogenic E. coli bacteria stimulates the mucosal immune system to produce specific antibodies as well as nonspecific secretory immunoglobulins.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02930970