Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

The aim of the study was to investigate the relationship between plasma levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity and oropharynx (OSCC). The prospective cohort study comprised a total of 67 patients who underwent surg...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2009-10, Vol.29 (10), p.4227-4231
Main Authors: SALZMAN, Richard, PACAL, Lukáš, TOMANDL, Josef, KANKOVA, Katerina, TOTHOVA, Eva, GAL, Bretislav, KOSTRICA, Rom, SALZMAN, Peter
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - blood
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - pathology
Cohort Studies
Female
Humans
Male
Malondialdehyde - blood
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Oropharyngeal Neoplasms - blood
Oropharyngeal Neoplasms - pathology
Otorhinolaryngology. Stomatology
Prognosis
Prospective Studies
Smoking - blood
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the study was to investigate the relationship between plasma levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity and oropharynx (OSCC). The prospective cohort study comprised a total of 67 patients who underwent surgery for OSCC. MDA was assessed using high performance liquid chromatography. The MDA levels in the pooled T1-2 patients were lower than in the patients with T3-4 tumors. A negative correlation of MDA and tumor grade was shown. Seventeen patients who manifested recurrence during the 49.6 months follow-up had significantly increased MDA compared to those staying in complete remission. Kaplan-Meier analysis revealed that the median disease-free interval and overall survival in the group with MDA>median was 19.3 and 22.5 months respectively, in contrast to 31.5 and 31.6 months respectively, in patients with MDA≤median. The prognostic value and low cost of MDA measurement could make it a versatile and useful prognostic tool for the identification of OSCC patients with a high risk of recurrence.
ISSN:0250-7005
1791-7530