Paeonol from Paeonia suffruticosa prevents TNF-α-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression

Paeonol (2′-hydroxy-4′-methoxyacetophenone), the main active compound of the radix of Paeonia suffruticosa, has been reported to have a beneficial effect in prevention and treatment of cardiovascular diseases. Vascular cell adhesion molecule-1 (VCAM-1), plays a crucial role in case of early inflamma...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2009-11, Vol.16 (11), p.1027-1032
Main Authors: Pan, L.L., Dai, M.
Format: Article
Language:English
Subjects:
Acetophenones - pharmacology
Animals
Atherosclerosis
Cell Adhesion - drug effects
Cells, Cultured
Endothelial Cells - drug effects
MAP Kinase Signaling System - drug effects
Mitogen-activated protein kinases
Monocytes - drug effects
Paeonia
Paeonia suffruticosa
Paeonol
Plant Extracts - pharmacology
Rat aortic endothelial cells
Rats
Rats, Sprague-Dawley
TNF-α
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1 - metabolism
VCAM-1
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Summary:Paeonol (2′-hydroxy-4′-methoxyacetophenone), the main active compound of the radix of Paeonia suffruticosa, has been reported to have a beneficial effect in prevention and treatment of cardiovascular diseases. Vascular cell adhesion molecule-1 (VCAM-1), plays a crucial role in case of early inflammatory responses, including atherosclerosis. In this study, we investigated the effect of paeonol on TNF-α-induced VCAM-1 expression in rat aortic endothelial cells (RAECs). The VCAM-1 expression in paeonol treated RAECs was measured. Paeonol inhibited TNF-α-induced VCAM-1 expression in a concentration-dependent manner. TNF-α induced p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) activities that contributed to VCAM-1expression was obviously attenuated after pre-treating RAECs with paeonol. The decrease of VCAM-1 expression by paeonol pretreatment led to a reduction of monocytes adhesion to RAECs. Taken together, our results demonstrated that paeonol inhibited VCAM-1 expression by the attenuation of p38 and ERK1/2 signal transduction pathways. We concluded that paeonol had the potential therapeutic development for use in anti-inflammatory and vascular disorders.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2009.04.003