Synthesis and antifungal activity of benzo[ d]oxazole-4,7-diones

Benzo[ d]oxazole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. Many of these tested compounds exhibited potent antifungal activity. Benzo[ d]oxazole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2009-10, Vol.19 (20), p.5924-5926
Main Authors: Ryu, Chung-Kyu, Lee, Ra-Young, Kim, Na Young, Kim, Yang Hui, Song, Ae Li
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial compounds
Benzo[ d]oxazole-4,7-diones
Biological and medical sciences
Fungi
Fungi - drug effects
Medical sciences
Microbial Sensitivity Tests
Oxazoles - chemical synthesis
Oxazoles - chemistry
Oxazoles - pharmacology
Pharmacology. Drug treatments
Structure-Activity Relationship
Substitution effects
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Summary:Benzo[ d]oxazole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. Many of these tested compounds exhibited potent antifungal activity. Benzo[ d]oxazole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that benzo[ d]oxazole-4,7-diones would be potent antifungal agents.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2009.08.062