Derivatization aids in the determination of end groups in poly(alkylene glycol)s by matrix-assisted laser desorption/ionization mass spectrometry

A method for end‐group characterization by matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry following preliminary derivatization with N,O‐bis(trimethylsilyl)trifluoroacetamide (BSTFA) and capryloyl chloride is described and applied to poly(alkylene glycol)s. The MALDI mass spect...

Full description

Saved in:
Bibliographic Details
Published in:Rapid communications in mass spectrometry 2009-10, Vol.23 (20), p.3309-3312
Main Authors: Borisov, Roman S., Polovkov, Nikolai Yu, Zaikin, Vladimir G.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A method for end‐group characterization by matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry following preliminary derivatization with N,O‐bis(trimethylsilyl)trifluoroacetamide (BSTFA) and capryloyl chloride is described and applied to poly(alkylene glycol)s. The MALDI mass spectra of the products revealed peaks of sodiated derivative cations, whose shift by the respective increments allowed the determination of the number of end functional groups with active hydrogens. This approach is particularly efficient for the distinction of cyclic and linear dehydration products among minor components. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.4251