Phosphoinositide 3-kinase-dependent activation of Rac

The monomeric GTPase Rac and the lipid kinase phosphoinositide 3-kinase (PI3K) are intracellular signalling enzymes that each regulate a huge range of cellular functions. Their signalling pathways overlap. Several pathways lead from PI3K activation via the production of the lipid second messenger ph...

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Bibliographic Details

Published in:	FEBS Letters 2003-07, Vol.546 (1), p.93-97
Main Authors:	Welch, Heidi C.E., Coadwell, W.John, Stephens, Len R., Hawkins, Phillip T.
Format:	Article
Language:	eng
Subjects:	Animals DH, Dbl homology Enzyme Activation Forecasting GDI, guanosine diphosphate dissociation inhibitor GEF, guanine-nucleotide exchange factor GTP Phosphohydrolases - metabolism GTPase Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - metabolism Guanine-nucleotide exchange factor Humans Models, Biological PH, plextrin homology Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - antagonists & inhibitors Phosphoinositide 3-kinase PI3K, phosphoinositide 3-kinase Protein Structure, Tertiary PtdIns(3,4,5)P3, phosphatidylinositol (3,4,5)-triphosphate Rac rac GTP-Binding Proteins - metabolism Second Messenger Systems Signal Transduction Signalling
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